$76 Cheap flights from McGhee Tyson to San Francisco Intl. (TYS to SFO)

Make sure you go to our Covid-19 Travel Advisor to learn if there are any present travel advice reports and quarantine requirements in place in SFO when flying in from McGhee Tyson Airport (TYS).

United Airlines, American Airlines and Delta will get you to San Francisco from Louisville with just one stopover. Unfortunately, there are no direct flights between TYS and SFO just yet.

For more info about changing your flight to SFO, please visit our Customer Service Portal.

It takes approximately 6 hours and 43 minutes to journey from Knoxville Airport to San Francisco Airport. You’ll be in the air for a while, so keep yourself amused with a film or get stuck into the airway’s magazines.

There’s a flight distance of 2,100 mi separating TYS and San Francisco Airport. This is classified as a medium-haul flight. There’ll be plenty of time to watch the in-flight entertainment and squeeze in some sleep if you’re feeling weary.

No airlines are currently offering direct flights between Knoxville Airport and San Francisco Airport. Save time and avoid annoying stopovers by researching the best routes in advance.

From the moment you enter the departure terminal to when you leave the arrivals terminal, if you’re flying with United Airlines, Alaska Airlines or Delta you can be sure that COVID-19 measures and social distancing rules have been adhered to. Many airlines have introduced capped capacity flights and keeping the middle seat empty.

This just in! Airfares offered on Thursdays tend to be the cheapest, according to flight demand on Travelocity in 2021. Tuesday and Wednesday prices are also good, but you may want to prepare your budget if booking during the weekend, as data shows that is when prices are generally at their highest.

Frequent travelers may already know this, but earlier in the week can be the cheapest time to fly. In 2021, flights departing on a Monday were generally the cheapest of the week, whereas you may pay a premium for weekend flights when demand is usually high. On average, tickets were most expensive for Saturday departures, so if you need to fly out on a weekend, you might look for deals ahead of time.

Trying to figure out how early you should book your flight? It’s possible to start comparing international airfares on Travelocity up to 12 months in advance. However, it does depend on the carrier as not all airlines release their prices that far out. According to our 2021 flight demand trends, last minute planners can still bag a bargain with some of the cheapest fares appearing 0-2 weeks prior to their travel dates.*According to flight demand on Travelocity.com from January to December 2021. Savings are subject to change based on departure location, date and destination.