American Airlines Flight 5221 Deals & Information (2025/2026)

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American Airlines Flight 5221 Route Deals From $301

The cheapest prices found with in the last 7 days for return flights were $389 and $301 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Apr 25 - Sun, Apr 27
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$389 Roundtrip, found 6 hours ago
$389
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Apr 25 from Lafayette Regional to Charlotte-Douglas Intl., returning Sun, Apr 27, priced at $389 found 6 hours ago
Fri, Apr 25 - Sun, Apr 27
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$398 Roundtrip, found 6 hours ago
$398
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Apr 25 from Lafayette Regional to Charlotte-Douglas Intl., returning Sun, Apr 27, priced at $398 found 6 hours ago
Fri, Apr 25 - Sun, Apr 27
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$423 Roundtrip, found 6 hours ago
$423
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Apr 25 from Lafayette Regional to Charlotte-Douglas Intl., returning Sun, Apr 27, priced at $423 found 6 hours ago
Fri, Apr 25 - Sun, Apr 27
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$429 Roundtrip, found 6 hours ago
$429
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Apr 25 from Lafayette Regional to Charlotte-Douglas Intl., returning Sun, Apr 27, priced at $429 found 6 hours ago
Tue, Jun 3 - Wed, Jun 25
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$429 Roundtrip, found 23 hours ago
$429
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Tue, Jun 3 from Lafayette Regional to Charlotte-Douglas Intl., returning Wed, Jun 25, priced at $429 found 23 hours ago
Sat, Jun 7 - Wed, Jun 25
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$435 Roundtrip, found 23 hours ago
$435
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Jun 7 from Lafayette Regional to Charlotte-Douglas Intl., returning Wed, Jun 25, priced at $435 found 23 hours ago
Tue, Jun 3 - Tue, Jun 24
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$439 Roundtrip, found 23 hours ago
$439
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Tue, Jun 3 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Jun 24, priced at $439 found 23 hours ago
Sun, Jun 8 - Wed, Jun 25
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$440 Roundtrip, found 23 hours ago
$440
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sun, Jun 8 from Lafayette Regional to Charlotte-Douglas Intl., returning Wed, Jun 25, priced at $440 found 23 hours ago
Sat, Jun 7 - Tue, Jun 24
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$445 Roundtrip, found 23 hours ago
$445
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Jun 7 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Jun 24, priced at $445 found 23 hours ago
Fri, Apr 25 - Sun, Apr 27
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$450 Roundtrip, found 6 hours ago
$450
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Apr 25 from Lafayette Regional to Charlotte-Douglas Intl., returning Sun, Apr 27, priced at $450 found 6 hours ago

Frequently asked questions

What route does flight number AA5221 take?
AA5221 is used on multiple routes. More commonly, AA5221 flies straight from Daytona Beach, FL Airport (DAB-Daytona Beach Intl.) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If you’ve booked a seat on this route, you’ll be up above the clouds for around 1 hour and 48 minutes.
How often is AA5221 on time?
If you’re traveling with American Airlines flight number AA5221 from DAB to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), it’s a relief knowing that their planes run according to schedule 92% of the time. In the rare event that a flight is running behind schedule, it should only be delayed by around 10 minutes. Thanks to this airline’s top standards, this flight has a 3.9-star rating.
What kind of plane is on flight number AA5221?
If you have a seat on flight AA5221 from Daytona Beach Intl. Airport (DAB) to Charlotte Airport, you’ll likely be aboard the Bombardier CRJ900. This flight number serves a number of routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5221 flight with Travelocity, please visit our Customer Service Portal.