American Airlines Flight AA5221 Deals & Information (2025/2026)

Wander Wisely with exceptional service, 24/7 supportOpens in a new window

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

American Airlines Flight 5221 Route Deals From $305

The cheapest prices found with in the last 7 days for return flights were $507 and $305 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Apr 4 - Sun, Apr 6
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$507 Roundtrip, found 3 days ago
$507
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Apr 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Sun, Apr 6, priced at $507 found 3 days ago
Fri, Apr 4 - Sun, Apr 6
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$517 Roundtrip, found 3 days ago
$517
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Apr 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Sun, Apr 6, priced at $517 found 3 days ago
Fri, Apr 4 - Sat, Apr 12
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$520 Roundtrip, found 4 days ago
$520
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Apr 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Sat, Apr 12, priced at $520 found 4 days ago
Sun, Apr 6 - Sat, Apr 12
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$523 Roundtrip, found 18 hours ago
$523
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Sun, Apr 6 from Lafayette Regional to Charlotte-Douglas Intl., returning Sat, Apr 12, priced at $523 found 18 hours ago
Mon, Apr 7 - Sat, Apr 12
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$525 Roundtrip, found 18 hours ago
$525
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Mon, Apr 7 from Lafayette Regional to Charlotte-Douglas Intl., returning Sat, Apr 12, priced at $525 found 18 hours ago
Sun, Apr 6 - Thu, Apr 17
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$560 Roundtrip, found 18 hours ago
$560
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Sun, Apr 6 from Lafayette Regional to Charlotte-Douglas Intl., returning Thu, Apr 17, priced at $560 found 18 hours ago
Mon, Apr 7 - Thu, Apr 17
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$562 Roundtrip, found 18 hours ago
$562
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Mon, Apr 7 from Lafayette Regional to Charlotte-Douglas Intl., returning Thu, Apr 17, priced at $562 found 18 hours ago

Frequently asked questions

What route does flight number AA5221 take?
AA5221 is used on multiple routes. More commonly, AA5221 flies straight from Daytona Beach, FL Airport (DAB-Daytona Beach Intl.) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If you’ve booked a seat on this route, you’ll be up above the clouds for around 1 hour and 48 minutes.
How often is AA5221 on time?
If you’re traveling with American Airlines flight number AA5221 from DAB to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), it’s a relief knowing that their planes run according to schedule 92% of the time. In the rare event that a flight is running behind schedule, it should only be delayed by around 10 minutes. Thanks to this airline’s top standards, this flight has a 3.9-star rating.
What kind of plane is on flight number AA5221?
If you have a seat on flight AA5221 from Daytona Beach Intl. Airport (DAB) to Charlotte Airport, you’ll likely be aboard the Bombardier CRJ900. This flight number serves a number of routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5221 flight with Travelocity, please visit our Customer Service Portal.