American Airlines Flight AA5221 Deals & Information (2025/2026)

Wander Wisely with exceptional service, 24/7 supportOpens in a new window

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

American Airlines Flight 5221 Route Deals From $185

The cheapest prices found with in the last 7 days for return flights were $361 and $185 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Mar 4 - Tue, Mar 11
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$361 Roundtrip, found 4 days ago
$361
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Mar 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Mar 11, priced at $361 found 4 days ago
Tue, Mar 4 - Tue, Mar 11
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$365 Roundtrip, found 4 days ago
$365
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Mar 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Mar 11, priced at $365 found 4 days ago
Tue, Mar 4 - Tue, Mar 11
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$366 Roundtrip, found 4 days ago
$366
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Mar 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Mar 11, priced at $366 found 4 days ago
Sat, Feb 15 - Mon, Feb 17
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$370 Roundtrip, found 6 days ago
$370
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Feb 15 from Lafayette Regional to Charlotte-Douglas Intl., returning Mon, Feb 17, priced at $370 found 6 days ago
Tue, Mar 4 - Tue, Mar 11
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$371 Roundtrip, found 4 days ago
$371
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Mar 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Mar 11, priced at $371 found 4 days ago
Tue, Mar 4 - Tue, Mar 11
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$380 Roundtrip, found 4 days ago
$380
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Mar 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Mar 11, priced at $380 found 4 days ago
Tue, Mar 4 - Tue, Mar 11
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$384 Roundtrip, found 4 days ago
$384
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Mar 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Mar 11, priced at $384 found 4 days ago
Tue, Feb 11 - Sat, Feb 15
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$390 Roundtrip, found 2 days ago
$390
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Feb 11 from Lafayette Regional to Charlotte-Douglas Intl., returning Sat, Feb 15, priced at $390 found 2 days ago
Tue, Mar 4 - Tue, Mar 11
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$394 Roundtrip, found 4 days ago
$394
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Mar 4 from Lafayette Regional to Charlotte-Douglas Intl., returning Tue, Mar 11, priced at $394 found 4 days ago
Sat, Feb 15 - Mon, Feb 17
LFT
Lafayette Regional
CLT
Charlotte-Douglas Intl.
$395 Roundtrip, found 6 days ago
$395
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Feb 15 from Lafayette Regional to Charlotte-Douglas Intl., returning Mon, Feb 17, priced at $395 found 6 days ago

Frequently asked questions

What route does flight number AA5221 take?
AA5221 is used on multiple routes. More commonly, AA5221 flies straight from Daytona Beach, FL Airport (DAB-Daytona Beach Intl.) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If you’ve booked a seat on this route, you’ll be up above the clouds for around 1 hour and 48 minutes.
How often is AA5221 on time?
If you’re traveling with American Airlines flight number AA5221 from DAB to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), it’s a relief knowing that their planes run according to schedule 92% of the time. In the rare event that a flight is running behind schedule, it should only be delayed by around 10 minutes. Thanks to this airline’s top standards, this flight has a 3.9-star rating.
What kind of plane is on flight number AA5221?
If you have a seat on flight AA5221 from Daytona Beach Intl. Airport (DAB) to Charlotte Airport, you’ll likely be aboard the Bombardier CRJ900. This flight number serves a number of routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5221 flight with Travelocity, please visit our Customer Service Portal.