Explore the best 2025 4 Star Hotels Hotels in Clayton
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Top Clayton 4 Star hotels

Hyatt Regency St. Louis at The Arch
315 Chestnut St, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $138 per night
$138
includes taxes & fees
$117 per night
May 22 - May 23
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a rooftop terrace on site, and a 24-hour front desk and a coffee shop are also provided.
Pet friendly
Free WiFi

Moonrise Hotel
6177 Delmar Blvd, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $200 per night
$200
includes taxes & fees
$168 per night
May 4 - May 5
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. Enjoy a meal from the a restaurant and perks like free self parking.
Pet friendly
Parking included

River City Casino & Hotel
777 River City Casino Blvd, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $126 per night
$126
includes taxes & fees
$108 per night
May 7 - May 8
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference space. Enjoy the 24-hour gym and perks like free self parking.
Parking included
Restaurant

DoubleTree by Hilton St. Louis Airport
4505 Woodson Road, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $129 per night
$129
includes taxes & fees
$110 per night
May 9 - May 10
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Bring the family and enjoy the arcade/game room and kid-friendly dining. Unwind with a drink at the bar/lounge and enjoy perks like free self parking and a free airport shuttle.
Pool
Free airport shuttle

21C Museum Hotel St Louis
1528 Locust street, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $193 per night
$193
includes taxes & fees
$165 per night
May 22 - May 23
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the gym and conveniences like a 24-hour front desk and concierge services.
Pool
Spa

Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $138 per night
$138
includes taxes & fees
$118 per night
May 23 - May 24
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and free airport shuttle. You'll appreciate the seasonal outdoor pool, bar/lounge, and laundry facilities.
Pool
Free airport shuttle

Ameristar Casino Resort and Spa
1 Ameristar Blvd, St. Charles, MO
Free Cancellation
Reserve now, pay when you stay
The price is $214 per night
$214
includes taxes & fees
$183 per night
Apr 30 - May 1
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside bar.
Pool
Hot Tub

Live by Loews - St.Louis
799 Clark ave, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $213 per night
$213
includes taxes & fees
$179 per night
May 26 - May 27
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a rooftop terrace on site, and concierge services and free newspapers are also offered.
Pet friendly
Free WiFi

Le Méridien St. Louis Clayton
7730 Bonhomme Ave, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $179 per night
$179
includes taxes & fees
$152 per night
May 4 - May 5
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a 24-hour gym on site, and a 24-hour front desk and a terrace are also provided.
Pool
Pet friendly

The Last Hotel
1501 Washington Ave, St. Louis, MO
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. A grocery/convenience store, a computer station, and luggage storage are also on offer.
Pool
Pet friendly

Embassy Suites by Hilton St. Louis Downtown
610 N 7th St, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The price is $157 per night
$157
includes taxes & fees
$132 per night
May 4 - May 5
This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, and valet parking. Relax with a drink at the bar/lounge and enjoy the free cooked-to-order breakfast.
Pool
Breakfast included

Hilton St. Louis Frontenac
1335 S Lindbergh Blvd, Frontenac, MO
Free Cancellation
Reserve now, pay when you stay
The price is $174 per night
$174
includes taxes & fees
$150 per night
May 4 - May 5
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport shuttle. Enjoy the seasonal outdoor pool and perks like free self parking and a free area shuttle.
Pool
Free airport shuttle
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Clayton hotels essential information
Accommodation | 1,795 hotels |
---|---|
Lowest Price | $126 |
Highest Price | $214 |
Popular hotels | Hyatt Regency St. Louis at The Arch, Moonrise Hotel, River City Casino & Hotel, DoubleTree by Hilton St. Louis Airport, 21C Museum Hotel St Louis , Renaissance St. Louis Airport Hotel, Ameristar Casino Resort and Spa, Live by Loews - St.Louis, Le Méridien St. Louis Clayton, The Last Hotel , Embassy Suites by Hilton St. Louis Downtown, Hilton St. Louis Frontenac |
Recent Clayton hotel reviews by fellow wanderers

Hollywood Casino & Hotel St. Louis
5 out of 5
Posted 19 hours ago
Travelocity Verified Review
"Great atmosphere and dining options are fabulous… quiet and safe location"
A verified traveler stayed at Hollywood Casino & Hotel St. Louis
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