Explore the best 2025 4 Star Hotels Hotels in Clayton

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Top Clayton 4 Star hotels

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Clayton hotels essential information

Accommodation
1,795 hotels
Lowest Price
$126
Highest Price
$214
Popular hotels
Hyatt Regency St. Louis at The Arch, Moonrise Hotel, River City Casino & Hotel, DoubleTree by Hilton St. Louis Airport, 21C Museum Hotel St Louis , Renaissance St. Louis Airport Hotel, Ameristar Casino Resort and Spa, Live by Loews - St.Louis, Le Méridien St. Louis Clayton, The Last Hotel , Embassy Suites by Hilton St. Louis Downtown, Hilton St. Louis Frontenac

Recent Clayton hotel reviews by fellow wanderers