American Airlines Flight AA4378 Deals & Information (2025/2026)

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American Airlines Flight 4378 Route Deals From $129

The cheapest prices found with in the last 7 days for return flights were $119 and $129 for one-way flights to Raleigh - Durham Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, May 20 - Wed, May 28
JFK
John F. Kennedy Intl.
RDU
Raleigh - Durham Intl.
$119 Roundtrip, found 1 day ago
$119
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 20 from John F. Kennedy Intl. to Raleigh - Durham Intl., returning Wed, May 28, priced at $119 found 1 day ago
Sat, Jul 12 - Tue, Jul 15
JFK
John F. Kennedy Intl.
RDU
Raleigh - Durham Intl.
$157 Roundtrip, found 14 hours ago
$157
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Sat, Jul 12 from John F. Kennedy Intl. to Raleigh - Durham Intl., returning Tue, Jul 15, priced at $157 found 14 hours ago
Tue, May 20 - Wed, May 28
JFK
John F. Kennedy Intl.
RDU
Raleigh - Durham Intl.
$160 Roundtrip, found 1 day ago
$160
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 20 from John F. Kennedy Intl. to Raleigh - Durham Intl., returning Wed, May 28, priced at $160 found 1 day ago
Sat, Apr 26 - Sat, May 3
JFK
John F. Kennedy Intl.
RDU
Raleigh - Durham Intl.
$163 Roundtrip, found 2 days ago
$163
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Apr 26 from John F. Kennedy Intl. to Raleigh - Durham Intl., returning Sat, May 3, priced at $163 found 2 days ago

Frequently asked questions

What route does flight number AA4378 take?
AA4378 takes multiple routes. The most popular is between Bloomington, IL Airport (BMI-Central Illinois Regional) and O’Hare Intl. Airport (ORD), which is a direct flight. This flight takes about 1 hour and 4 minutes. However, there may be other flights with the same number that are multi-stop.
What kind of plane is on flight number AA4378?
Chances are you’ll travel aboard the Embraer RJ145 if you’ve booked a seat on flight number AA4378 from Central Illinois Regional Airport (BMI) to O’Hare Airport. This is the most commonly used aircraft model on this particular route.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4378 flight with Travelocity, please visit our Customer Service Portal.