
$116 Cheap American Airlines flights from San Diego to Knoxville (SAN to TYS)
Find The Best Day To Fly from San Diego to Knoxville
Amazing American Airlines SAN to TYS Flight Deals
The cheapest flights to McGhee Tyson found within the past 7 days were $243 round trip and $116 one way. Prices and availability subject to change. Additional terms may apply.
TYS From SAN Economy Coach Packages on Similar Airlines



Frequently asked questions
Discover our best American Airlines flight from San Diego SAN to Knoxville TYS
To find the best deals on flights to San Diego from Knoxville with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from San Diego SAN to Knoxville TYS with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $243 to $299, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from San Diego SAN to Knoxville TYS
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from San Diego to Knoxville costs from $116. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Knoxville TYS from San Diego SAN with American Airlines
To find a cheap American Airlines flight from San Diego SAN to Knoxville TYS, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from San Diego SAN to Knoxville TYS
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as May, or if you book a flight with a stopover.
Find nonstop flights from San Diego SAN to Knoxville TYS with American Airlines
If you’re keen to be on Knoxville soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from San Diego SAN to Knoxville TYS
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Knoxville TYS from San Diego SAN with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Airport code | Country | Airport name | Number of flights |
---|---|---|---|
DFW | USA | Dallas-Fort Worth Intl. | 599 |
CLT | USA | Charlotte-Douglas Intl. | 536 |
ORD | USA | O'Hare Intl. | 317 |
PHL | USA | Philadelphia Intl. | 247 |
MIA | USA | Miami Intl. | 193 |
DCA | USA | Ronald Reagan Washington National | 152 |
PHX | USA | Sky Harbor Intl. | 141 |
LAX | USA | Los Angeles Intl. | 81 |
LGA | USA | LaGuardia | 72 |
BOS | USA | Logan Intl. | 57 |
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Popular American Airlines Flight Routes from SAN
- American Airlines SAN to MCO
- American Airlines SAN to ORD
- American Airlines SAN to IAH
- American Airlines SAN to BOS
- American Airlines SAN to EWR
- American Airlines SAN to MSP
- American Airlines SAN to LGA
- American Airlines SAN to JFK
- American Airlines SAN to LHR
- American Airlines SAN to LAS
- American Airlines SAN to FLL
- American Airlines SAN to FCO
Top American Airlines Flight Routes from TYS
- American Airlines TYS to MCI
- American Airlines TYS to MIA
- American Airlines TYS to CLE
- American Airlines TYS to SNA
- American Airlines TYS to BZE
- American Airlines TYS to PHX
- American Airlines TYS to SFO
- American Airlines TYS to LGA
- American Airlines TYS to MSY
- American Airlines TYS to ONT
- American Airlines TYS to ORD
Top Flights for American Airlines originating from SAN
Domestic
- New York to Orlando (LGA - MCO)
- New York to San Juan (JFK - SJU)
- Newark Liberty Intl. Airport to Miami (EWR - MIA)
- New York to Orlando (LGA - MCO)
- Philadelphia to Orlando (PHL - MCO)
- Dallas to Las Vegas (DFW - LAS)
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- New York to Orlando (JFK - MCO)
- Philadelphia to Orlando (PHL - MCO)
- Orlando to San Juan (MCO - SJU)
International
- New York to San Juan (JFK - SJU)
- Newark Liberty Intl. Airport to Las Vegas (EWR - LAS)
- Newark Liberty Intl. Airport to Miami (EWR - MIA)
- Philadelphia to Orlando (PHL - MCO)
- Los Angeles to San Salvador (LAX - SAL)
- New York to Santiago (JFK - STI)
- New York to Orlando (JFK - MCO)
- Los Angeles to San Salvador (LAX - SAL)
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- Lisbon to Toronto (LIS - YYZ)