Cheap American Airlines flights from Columbus to Florence (CMH to FLO)

Find The Best Day To Fly from Columbus to Florence

Amazing American Airlines CMH to FLO Flight Deals

The cheapest flights to Florence Regional found within the past 7 days were $368 round trip and one way. Prices and availability subject to change. Additional terms may apply.

FLO From CMH Economy Coach Packages on Similar Airlines

Price found within the past 48 hours. Click for updated prices.
Americas Best Value Inn Bishopville
La Quinta Inn & Suites by Wyndham Florence
Days Inn by Wyndham Florence Near Civic Center
Don't see what you're looking for?
See all available trips from John Glenn Columbus Intl. to Florence Regional
View all trips

Frequently asked questions

Can I catch a flight from CMH to Florence Regional Airport right now?
Ensure you check out our Covid-19 Travel Advisor to discover if there are any current travel advice reports or quarantine requirements in place in Florence Regional Airport when jet-setting from CMH.
What terminal is American Airlines at John Glenn Columbus Intl. Airport (CMH)?
You should find out exactly which terminal American Airlines departs from at John Glenn Columbus Intl. Airport (CMH) once you receive your boarding pass. The same applies to information regarding your arrival at Florence Regional Airport (FLO). If those details are missing, contact your airline.
Are there American Airlines non-stop flights from CMH to FLO?
You won’t find any nonstop flights with American Airlines from CMH to FLO. You will have a stopover, so take the opportunity to go for a stroll and stretch out those legs before your next flight.
How long is an American Airlines flight from CMH to FLO?
Your American Airlines flight will get you from John Glenn Intl. Airport to FLO in roughly 2 hours and 56 minutes. If you’re not a big fan of talking to fellow travelers while you’re thousands of feet in the air, don’t worry — you won’t have to make polite conversation for too long.
How many direct and indirect flights does American Airlines fly from CMH to FLO?
American Airlines currently operates no fewer than 2 flights every day from John Glenn Intl. Airport to FLO.
If I am not able to travel due to COVID-19, can I change my booking to a later date?
For more info about changing your flight to FLO, please visit our Customer Service Portal.
What is the best day to buy a plane ticket?
This just in! Airfares offered on Thursdays tend to be the cheapest, according to flight demand on Travelocity in 2021. Tuesday and Wednesday prices are also good, but you may want to prepare your budget if booking during the weekend, as data shows that is when prices are generally at their highest.
What are the cheapest days to fly?
Frequent travelers may already know this, but earlier in the week can be the cheapest time to fly. In 2021, flights departing on a Monday were generally the cheapest of the week, whereas you may pay a premium for weekend flights when demand is usually high. On average, tickets were most expensive for Saturday departures, so if you need to fly out on a weekend, you might look for deals ahead of time.
How far in advance can you book a flight?
Trying to figure out how early you should book your flight? It’s possible to start comparing international airfares on Travelocity up to 12 months in advance. However, it does depend on the carrier as not all airlines release their prices that far out. According to our 2021 flight demand trends, last minute planners can still bag a bargain with some of the cheapest fares appearing 0-2 weeks prior to their travel dates.*According to flight demand on Travelocity.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Discover our best American Airlines flight from Columbus CMH to Florence FLO 

To find the best deals on flights to Columbus from Florence with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.  

 

Return flights from Columbus CMH to Florence FLO with American Airlines 

If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $368 to $507, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply. 

 

Book one-way American Airlines flights from Columbus CMH to Florence FLO 

A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Columbus to Florence costs from . Prices and availability subject to change. Additional terms may apply. 

 

The easy way to find cheap flights to Florence FLO from  Columbus CMH with American Airlines 

To find a cheap American Airlines flight from Columbus CMH to Florence FLO, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference. 

 

How to find our best airfare deals on American Airlines flights from Columbus CMH to Florence FLO 

If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as July, or if you book a flight with a stopover. 

 

Find nonstop flights from Columbus CMH to Florence FLO with American Airlines 

If you’re keen to be on Florence soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it. 

 

Flexible airline tickets for American Airlines flights from Columbus CMH to Florence FLO 

Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.  

 

There are a lot of reasons to book your flights to Florence FLO from  Columbus CMH with American Airlines on Travelocity 

At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.

American Airlines Airports
Hop on a(n) American Airlines flight today by flying to many destinations out of these domestic and international airports:
Airport code
Country
Airport name
Number of flights
DFWUSADallas-Fort Worth Intl.599
CLTUSACharlotte-Douglas Intl.536
ORDUSAO'Hare Intl.317
PHLUSAPhiladelphia Intl.247
MIAUSAMiami Intl.193
DCAUSARonald Reagan Washington National152
PHXUSASky Harbor Intl.141
LAXUSALos Angeles Intl.81
LGAUSALaGuardia72
BOSUSALogan Intl.57

Travelers ❤️ these 🏨 after their flight to Florence

Hyatt Place Florence Downtown
Hyatt Place Florence Downtown
3 out of 5
100 East Evans Street Florence, Florence, SC
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
8.6/10 Excellent! (1,008 reviews)
"From start to finish our stay was really nice. Staff was great, rooms were clean, beds were comfy. A few minor things: housekeeping forgot to wipe down the desk (no biggie), the pool needed to have the net swept thru it (little leaves around the edge by the stairs) and the front outside seating area ..."

Reviewed on Apr 21, 2025

Hyatt Place Florence Downtown
Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.
Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.
Florence
This vacation home features laundry facilities.
10/10 Exceptional! (2 reviews)
Clean, easy stay in Florence
"Our host David is wonderful and he accommodated us over the holidays with some short notice. The property is very clean and well kept. Check in and out was easy. There are plenty of towels and the kitchen has everything you’d need for a comfortable stay. I appreciated how easy it was to communicate ..."

Reviewed on Dec 26, 2024

Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.
Hotel Florence, Tapestry Collection by Hilton
Hotel Florence, Tapestry Collection by Hilton
3 out of 5
126 W Evans St, Florence, SC
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
8.8/10 Excellent! (564 reviews)
Hotel with character
"Staff was great, room was very good. It was very noisy outside and you can hear everything if you face the front."

Reviewed on Apr 20, 2025

Hotel Florence, Tapestry Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.